Ampicillin (Amoxivet) 500MG 12 Caps, Amoxicilina
Each capsule contains:
equivalent to ............................... 500 mg
Excipient cbp 1 capsule.
It is indicated for the treatment of the following infections due to susceptible strains of Gram-positive and Gram-negative bacteria: respiratory tract infections. Bacterial meningitis (adding an aminoglycoside may increase the effectiveness of ampicillin against bacteria grannegativas in particular). Septicemia and endocarditis (the addition of an aminoglycoside may enhance the effectiveness of ampicillin in the case of enterococcal endocarditis). Gastrointestinal infections.
Ampicillin is well absorbed from the gastrointestinal tract, is stable in the presence of gastric acid. Diffuses rapidly in most tissues and fluids. However, penetrates the cerebrospinal fluid and brain only when the meninges are inflamed. Ampicillin is excreted in large quantities in the urine unchanged and that removal can be delayed by concurrent administration of probenecid. The active form is found in bile in higher concentrations in the serum of all penicillins, which is fixed at least the ampicillin serum is about 20%, compared with approximately 60-90%. Is destroyed lactamase produced by gram-positive and gram-negative and, therefore, is ineffective in the majority of infections caused by staphylococci. It has been shown in in vitro studies that the majority of the following bacteria are susceptible to ampicillin: Gram-positive: Streptococcus haemolyticus and haemolyticus, premonial.
Ampicillin is contraindicated in patients who have had previous hypersensitivity reactions to penicillins.
Before prescribing the drug, ask the patient about the previous presentation of allergic reactions to penicillin. A negative test for allergies to penicillin, does not guarantee that in the future there will be an allergic reaction to penicillin. The sensitivity of each person to the drug is variable when allergic reactions occur, they may include: rash, pruritus (itching), asthma, swelling of the hands, lips, eyelids and joints, fever and anaphylactic shock and can cause reactions of various sizes ranging from mild to severe. Penicillin is a useful drug that only the physician based on the above reactions in the patient produced either by the use of the drug or any other factor allergenic (including food source) can determine whether or not this product be administered.
RESTRICTIONS OF USE DURING PREGNANCY AND BREASTFEEDING
Use during pregnancy, ampicillin safety during pregnancy has not been established. Should not be used in pregnant women unless, in the opinion of the physician, the benefits are more important than the potential risk to the fetus. Lactation-have been detected in small amounts in breast milk ampicillin so caution should be exercised when administering ampicillin to a woman who is breastfeeding.
Hypersensitivity reactions may occur, as with any penicillin.
Are presented in individuals who have previously been shown to be hypersensitive to penicillins and in those with a history of allergy, asthma, hay fever or urticaria.
They have shown the following adverse reactions with the use of ampicillin:
Gastrointestinal: glossitis, estomagitis, glosafitia, vomiting, enterocolitis, pseudomembranous colitis, and diarrhea (these reactions are associated with the oral form).
Hypersensitivity Reactions: Have been reported skin rashes and hives, as well as some cases of dermatitis.
Note: The hives and other rashes can be treated with antihistamines and, if necessary with systemic corticosteroids. Whenever such reactions occur, ampicillin should be discontinued, unless in the opinion of the medical condition being treated is life threatening or just respond to treatment with ampicillin.
Serious anaphylactoid reactions require immediate use of epinephrine, oxygen, and intravenous steroids.
Liver: There has been moderate elevation of serum glutamic transaminase (SGOT), especially in infants, but it is unknown clinical significance of this finding.
Hematologic and Lymphatic: During treatment with penicillins have been reported anemia, thrombocytopenia, thrombocytopenic purpura, cosmofilia, leucopenia and agranulocytosis. These reactions are usually reversed on discontinuation of treatment.
DRUG INTERACTIONS AND OTHER GENDER
The rate of excretion of penicillins is reduced by concomitant administration of probenecid, probenecid prolongs and carries blood concentrations of penicillins. Patients receiving allopurinol for hyperuricemia seem to be predisposed to developing induced rash ampicillin. Ampicillin has been associated with a reduction in urinary excretion of estrogen in pregnant women with isolated reports of menstrual irregularities and unintended pregnancies in patients receiving oral contraceptives.
CHANGES IN RESULTS OF LABORATORY TESTS
The penicillins may interfere with the detection method used glucosuria copper sulfate reagent, which results in falsely high or low readings. This interference does not occur with the method of the glucose oxidase.
PRECAUTIONS IN RELATION TO EFFECTS Carcinogenesis, Mutagenesis, Impairment of Fertility
No studies have been performed in animals prolonged observation with ampicillin.
DOSAGE AND ADMINISTRATION
MANIFESTATIONS AND MANAGEMENT OF OVERDOSE OR ACCIDENTAL INGESTION
In case of overdose, discontinue medication, treat symptomatically and institute patient support measures required. In patients with impaired renal function, antibiotic ampicillin can be removed by hemodialysis but not by peritoneal dialysis.
Bottle with 12 capsules of 500 mg. Bottle with 28 capsules of 500 mg.
Keep the bottle tightly closed at room temperature to no more than 30 ° C and dry.